Hello if you listen to music with the native app you can do it, but qualitatively it is not the best, very basic sound. I'd recommend the classic HomePod, then possibly use the mini as a filler via airplay2. (If your Mac is recent).
If you use video editing apps instead, you can go into settings and divert the computer's output sound to Homepod.
I use Airfoil to run a mixed system, 4 HomePods and 2 Naim.
Super-performing solution.