Yes, the monitor can be used with a Mac M4 mini as the first monitor as long as the Mac's USB-C port supports display output. The monitor uses a single USB-C connection for power and video signal, allowing for easy connection. It is important that the USB-C port of the Mac M4 mini supports DisplayPort output so that the image can be transmitted.

There are reports that ASUS ZenScreen models are compatible with macOS, however the ASUS DisplayWidget software is mainly for Windows and not available for macOS. Nevertheless, pure video transmission via USB-C usually works without any problems if the Mac supports display output.