The SanDisk Ultra SDHC card with UHS-I is generally compatible with cameras that support SDHC cards. The Nikon Z 6 II supports SDXC cards, which also accept SDHC cards. Therefore, the card should generally work unless there are specific restrictions or requirements for the Nikon Z 6 II that are not included in the general specifications. It is always advisable to check the official specifications of the camera to ensure that there are no specific requirements for the card type.