When using the Denon Home 350 in addition to cable-driven speakers in the same room, there might be a delay effect if the audio is being synchronized across multiple HEOS speakers. The HEOS system buffers audio to ensure synchronization, which can cause a delay when using inputs like the AUX connection with a TV. However, if you're only using the Home 350 without multi-room synchronization, the delay should not be noticeable.