The docking station is definitely compatible with the hardware, as the Aspire E 15-576G has USB 3.0 ports. USB 3.0 is a manufacturer-independent standard interface. So it depends much more on the operating system that is installed on it. Drivers from Targus are available for Windows (from version 7), for Mac OS X (from version 10.9 and for Linux only for Ubuntu (from version 14.04).