Hello, yes you can use it to vacuum mattresses, but only with air. There is a suitable nozzle, but the mattress is only vacuumed and the dirt and mites are trapped in the water. Unfortunately, the cleaning attachment that sprays water with cleaning agent onto the mattress does not work with this model. For this you need the Thomas Aqua+ Pet and Family model, which is only slightly more expensive. Hope this helps.

Yes, with the mattress cleaning attachment.