I would start with the basic game. Afterwards, the first expansion "Troublemaker" is recommended. You can also start directly with Basis + Troublemaker - that works too. I would only buy Supercharched and Pandora's Box at a later stage, otherwise there is a lot to complain about at the beginning.

We started with the basic game. After we had a great time every evening, afternoon and early morning for 2 weeks during the holidays, we bought the expansions that suited our taste.