The Gigabyte A320M-S2H is a micro-ATX motherboard that features a fast PCI-Express 3.0 slot with full x16 bandwidth for graphics cards. Additionally, there are two PCIe x1 slots available for other expansion cards. The two RAM slots can accommodate up to 32 GB of DDR4 memory, with compatible memory running at a maximum of 3200 overclocked megahertz. The internal connection options include a header for USB 3.0 and two USB 2.0 ports, allowing for two or four ports in total. The board manages storage devices like SSDs and hard drives through four SATA 6G connectors (including RAID support).

Notably, the Gigabyte A320M-S2H also features a USB 3.1 port on the I/O shield and five temperature sensors. Lastly, two fans with 4-pin PWM connectors can be directly connected to the motherboard. On the back of the motherboard, additional devices and components can be connected via USB 3.1 and 2.0, Gigabit LAN, PS/2, or three audio jacks through the I/O shield. For display output via the integrated APU graphics unit (optional), three monitor outputs are available: HDMI, DVI-D, and VGA.