This 16GB RAM is 100% compatible with Asus ESC4000/IB. Information on memory configuration: The following technical specifications should be considered in advance: ECC DIMM (with Error-Correction-Code) or RDIMM (Registered DIMM) RAM can be installed in the device. RDIMM memory is recommended when large memory capacities are required. The different memory technologies (ECC / RDIMM) must not be mixed. If a memory upgrade is to be performed with the existing RAM, it must be checked which memory technology (ECC / RDIMM) is present. A higher memory clock of the memory module automatically adjusts to the memory clock set by the system. This can especially be the case with larger capacities. Memory slots without a processor present must not be populated.