This 64GB RAM is 100% compatible with the Asus ESC8000 G3.

Information on memory configuration: The following technical specifications should be considered in advance: The device can be equipped with RDIMM and RDIMM 3DS (Registered DIMM) or LRDIMM and LRDIMM 3DS (Load Reduced DIMM) RAM. LRDIMM memory is recommended for achieving large memory capacities. RDIMM and RDIMM 3DS memory modules cannot be mixed with LRDIMM and LRDIMM 3DS memory. If a memory expansion is to be carried out with the existing RAM, it must be checked which base memory technology (RDIMM / LRDIMM) is present. Memory slots without a processor must not be populated. A higher memory clock of the memory module automatically adjusts to the memory clock specified by the system. This can especially be the case with larger capacities.