This 16GB RAM is 100% compatible with the Lenovo ThinkSystem SR250 V2 (7D8F). During system startup, a special memory query is initiated. The memory from the system manufacturer not only has technical specifications but also a manufacturer number. The system recognizes the memory as qualified based on the manufacturer number. Compatible memory does not have this manufacturer number, but the technical specifications are identical. When using compatible memory, a message must be confirmed by pressing a key during system startup. After this confirmation, the compatible memory will also function seamlessly in the system.