This 16GB RAM is 100% compatible with Supermicro A+ Server 4022G-6F. Information on memory configuration: The following technical specifications should be considered in advance: ECC DIMM (with Error-Correction Code) or RDIMM (Registered DIMM) RAM can be installed in the device. RDIMM memory is recommended when large memory capacities are required. The different memory technologies (ECC / RDIMM) must not be mixed. If a memory upgrade is to be made with the existing RAM, it must be checked which memory technology (ECC / RDIMM) is present. Memory slots without a processor should not be populated. When using a multiprocessor system, the memory slots should always be populated identically for each CPU. A higher memory clock of the memory module automatically adjusts to the memory clock specified by the system, which can especially be the case with larger capacities. Memory configuration for system performance: Optimal performance is achieved with 4 or 8 identical memory modules per CPU. The memory should be populated identically per CPU (mirrored to the other CPU).