This 64GB RAM is 100% compatible with Supermicro A+ Server E301-9D-8CN4. Information on memory configuration: The following technical specifications should be considered in advance: RDIMM (Registered DIMM) or LRDIMM (Load Reduced DIMM) RAM can be installed in the device. LRDIMM memory is recommended for achieving large memory capacities. RDIMM memory modules cannot be mixed with LRDIMM memory. If a memory upgrade is to be performed with the existing RAM, it must be checked which memory technology (RDIMM / LRDIMM) is currently in use. If memory modules with higher clock rates than specified by the system are offered, the memory clock will automatically adjust to the system specifications.