It says on the Noctua website that the cooler is compatible with the sWRX8 socket, but the cooler is rotated 90 degrees and the fan blows from the bottom up, as I have seen some sWRX8 motherboards that have the socket rotated. RAM clearance should not be a problem if the RAMs are not higher.

I have it in use with only a 2950X with a second fan on the cooler. Room temperature warm at 25°. Case with some insulation, so airflow-wise not ideal. At limit 180W (i.e. significantly lower than yours) the temps are already approaching 68 degrees. But it's quite enough to get above the base clock. I can hear the part quite clearly, but I don't know how other fans make noise. A water cooling system broke after a short time. The selection for Threadripper-adapted AiO is unfortunately very narrow. The 280W would worry me a bit. An airy case and a cool environment will certainly help. According to Noctua it works, but Turbo is nothing: https://noctua.at/de...

Yes it‘s a good cooler. I‘m using the 3970x and tried the push-pull version with it. I don‘t know the temperature but it‘s not getting hot.

...bei Noctua direkt: https://noctua.at/de...