The MSI B550 GAMING GEN3 motherboard supports both M.2 SSDs and NVIDIA GeForce RTX 3060 graphics cards without any loss of performance, provided that the components are compatible with the specifications of the motherboard.

- M.2: The mainboard has an M.2 slot that accepts M.2 SSDs with PCIe 3.0 x4 and SATA support.
- RTX 3060: The NVIDIA GeForce RTX 3060 is a PCIe 3.0 x16 card, and the motherboard has two PCIe x16 slots that support this card.

However, it is important to ensure that the processor and power supply provide sufficient power to support all components.