Not necessarily, with WD and other vendors you canot be sure that WD is using SATA drives in USB enclosures. If you have bad luck you will notice after opening the case that the vendor used a USB board on the HD and then you are really out of luck. The only company you can trust on buying external 2.5 inch USB crives is Seagate, every 5 TB external USB drive is using the Seagate Barracuda 5TB disks, you can remove the case and then use this Seagate disk in a NAS and if you use 2.5 inch drives with 5TB size in your NAS you would also save a lot of energy and weight also.

Will try on my new Synology NAS with Seagate and WD. Thank you!