The ThunderboltEX 5 card is a PCI Express x4 plug-in card with Thunderbolt 5 USB-C connections. Compatibility with the MSI MPG X570S Edge MAX motherboard depends on whether the motherboard has a suitable PCIe x4 slot and a Thunderbolt header.

The MSI MPG X570S Edge MAX motherboard has PCIe 4.0 slots, including x4 slots, which is generally suitable for the plug-in card. However, the ThunderboltEX 5 card requires a special Thunderbolt header on the mainboard, which is available on ASUS mainboards but is not always installed as standard on MSI mainboards.

As the official ASUS compatibility list for the ThunderboltEX 5 card only lists ASUS mainboards and does not mention any MSI models, compatibility with the MSI MPG X570S Edge MAX is not guaranteed. The card cannot be fully utilised without the appropriate Thunderbolt header on the MSI mainboard.

To summarise: The card fits mechanically into the PCIe x4 slot of the MSI MPG X570S Edge MAX, but the full functionality of the ThunderboltEX 5 card requires a Thunderbolt header, which is probably not present on this MSI mainboard. Therefore, compatibility is not given.