Yes, this motherboard is compatible with a PCIe 5.0 SSD. It has an M.2 slot (M.2_1) that supports PCIe 5.0 x4, connected directly to the processor for optimum performance.

To take full advantage of PCIe 5.0 speeds, you need to pair this motherboard with an AMD Ryzen 9000 or 7000 series processor, as these offer native PCIe 5.0 support. Ryzen 8000 Series processors only support PCIe 4.0 on this motherboard.