Sure. Simply insert it into the top slot and plug in the 8pin PCIe power cable. The power supply should be a decent one with enough power.

Your motherboard is in PCIE 3.0 whereas the card is in PCIE 4.0.
If you look on the web, there's sometimes an incompatibility (sometimes), but it's a problem with the motherboard... I think you'd better ask people who have bought the same motherboard, to find out if they've had a problem with PCIE 4.0 cards...

Otherwise, 650w minimum power supply.