If this question means whether the M.2 still fits on the motherboard, then I can tell you that it should not matter how big your GPU is. Since there is still a gap between the GPU and the motherboard. But you should make sure that it can be cooled. Because of the high read and write rates, it can get quite warm, especially behind the GPU. Many of the newer motherboards come with a plate with a heat pad that can dissipate the heat. And there are also relatively thin heat sinks.