No, you cannot connect two Logitech Spotlight presenters to the same Mac at the same time to control the same PowerPoint presentation independently. Each presenter only supports one Bluetooth or USB connection per device, and simultaneous use of multiple remotes on one Mac is not supported as they would interfere with each other. The product information does not specify multi-remote functions, and official Logitech documents only describe single connections. I'm not entirely sure about specific software options for multiple remotes, as the data doesn't fully cover that. Check our Community for more tips.