Yes, the NZXT Kraken X53 water cooler is compatible with the AMD Ryzen 7 5900X processor. The Kraken X53 supports the AM4 socket on which the Ryzen 7 5900X is based and is suitable for a wide range of AMD and Intel processors. Before installing the cooler, however, you should ensure that your computer's case offers sufficient space and that the cooler does not collide with other components